International journal of clinical practice
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Int. J. Clin. Pract. · Mar 2021
Possible role of the receptor of advanced glycation end products (RAGE) in the clinical course of prostate neoplasia in patients with and without type 2 diabetes mellitus.
The expression of the cognate receptor of advanced glycation end products (RAGE) in malignant tissues of patients with type 2 diabetes has been suggested as a co-factor determining the clinical course and prognosis. We aimed to investigate the relationship between RAGE expression and clinicopathological features of prostate neoplasia. ⋯ We found higher RAGE expression levels in malignant prostate neoplasia than in BPH. As expected, patients with diabetes had higher scores than control patients. Disease progression and survival parameters were worse in patients with high RAGE levels. RAGE expression may be a useful biomarker for the diagnosis and prognosis of prostate cancer.
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Int. J. Clin. Pract. · Mar 2021
Ectopic eruption of maxillary permanent first molars: Predictive factors for self-corrected and impacted outcome.
The aim of this study was to describe the occurrence, angulation and mesialisation ratio of the ectopic eruption of the maxillary permanent first molar (PFM) and its correlation with the pathological resorption of maxillary primary second molar (PSM). ⋯ Even if eruption disturbances do not occur frequently, making an early diagnosis is important to begin treatment at an optimal time. Although the relationship between horizontal and vertical angles and the ectopic eruption pattern is controversial, it is one of the clinical determinants. The mesialisation ratio of the impacted type was significantly higher than the self-corrected type. Self-correction of PFM was reduced in PSM with grade III and IV root resorption.
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Int. J. Clin. Pract. · Mar 2021
Saxagliptin and Vildagliptin Lowered Albuminuria in Patients with Diabetes and Hypertension Independent on Glycemic Control.
Preclinical data illustrated that the dipeptidyl peptidase-4(DPP-4) inhibitors did lower urinary albumin excretion in diabetes-induced rats. We evaluated the effects of saxagliptin and vildagliptin on albuminuria in patients with diabetic nephropathy on top of the renin-angiotensin-aldosterone system (RAAS) blockade therapy. ⋯ DPP-4 inhibitors, saxagliptin, and vildagliptin, resulted in substantial reductions in albuminuria in patients with T2D and hypertension on top of RAAS blockade after short term therapy independently on glycaemic or hemodynamic changes. Saxagliptin was superior to vildagliptin in albuminuria-categorical shifting.
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Int. J. Clin. Pract. · Mar 2021
Informed consent disclosure to vaccine trial subjects of risk of COVID-19 vaccines worsening clinical disease.
Patient comprehension is a critical part of meeting medical ethics standards of informed consent in study designs. The aim of the study was to determine if sufficient literature exists to require clinicians to disclose the specific risk that COVID-19 vaccines could worsen disease upon exposure to challenge or circulating virus. ⋯ The specific and significant COVID-19 risk of ADE should have been and should be prominently and independently disclosed to research subjects currently in vaccine trials, as well as those being recruited for the trials and future patients after vaccine approval, in order to meet the medical ethics standard of patient comprehension for informed consent.