British journal of haematology
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Multicenter Study Clinical Trial
Malignancy-associated haemophagocytic lymphohistiocytosis in children and adolescents.
Haemophagocytic lymphohistiocytosis (HLH) in the context of malignancy is mainly considered a challenge of adult haematology. While this association is also observed in children, little is known regarding inciting factors, appropriate treatment and prognosis. We retrospectively analysed 29 paediatric and adolescent patients for presenting features, type of neoplasm or preceding chemotherapy, treatment and outcome. ⋯ Seven of 11 deceased M-HLH patients exhibited active malignancy and HLH at the time of death, while only two out of five deceased Ch-HLH patients had evidence of active HLH. To overcome HLH, malignancy- and HLH-directed treatments were administered in the M-HLH cohort; however, it was not possible to determine superiority of one approach over the other. For Ch-HLH, treatment ranged from postponement of chemotherapy to the use of etoposide-containing regimens.
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Review Meta Analysis
Prognostic value of interim FDG-PET in Hodgkin lymphoma: systematic review and meta-analysis.
This study aimed to systematically review and meta-analyse the value of interim (18) F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) in predicting treatment failure in Hodgkin lymphoma. MEDLINE was systematically searched for original studies that used standardized international criteria for interim FDG-PET interpretation. Included studies were methodologically assessed. ⋯ There was heterogeneity in DORs across individual studies (I2 = 72.7). The overall prognostic value of interim FDG-PET appears to be moderate for excluding and relatively high for identifying treatment failure in Hodgkin lymphoma. However, interim FDG-PET cannot yet be implemented in routine clinical practice due to moderate-quality evidence and inter-study heterogeneity that cannot be fully explained yet.