European journal of pain : EJP
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It is well known that neuropeptide Y (NPY) participates in the modulation of chronic pain, but its exact role has not yet been fully explained. In this study, we explored whether targeted delivery of NPY and its antagonists into dorsal root ganglion (DRG) modulates pain-related behaviour in rats with experimentally induced inflammatory nociception. ⋯ These findings indicate an important link between pain-related behaviour and neuroimmune actions of NPY Y1 and Y2 receptors.
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Pain from the musculoskeletal system often occurs in more than one site. This appears to affect prognosis negatively. Knowledge about specific pain patterns is lacking. ⋯ Unique clusters of musculoskeletal co-complaints can be determined based on primary pain site. These patterns are different for persons with a primary complaint in the spine compared with persons with a primary complaint in the extremities.
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Numerous studies focus on intramuscular (i.m.) injection of hypertonic saline-induced muscle pain and nociception. The spatio-temporal characteristics and dynamic variation of spinal neuronal activities elicited by i.m. hypertonic saline remain unknown. ⋯ It is suggested that spinal nociceptive neuronal activities in superficial and deep layers may differently be modulated by endogenous descending facilitation and inhibition, respectively.
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Randomized Controlled Trial
Reliability and validity of a continuous pain registration procedure.
Conventional pain rating scales [i.e. visual analogue scales (VAS) or numerical rating scales (NRS)] only provide a summary for different levels of pain felt, while the duration of these levels is not accounted for. If pain can be rated continuously, the area under the curve (AUC) of varying pain intensity over time can be calculated, which integrates varying pain intensity with duration. The present study examined the reproducibility and validity of a continuous pain rating procedure. ⋯ A continuous pain registration procedure, using an AUC approach, may be a promising direction to explore. Results can be improved by allowing more training on the use of the electronic VAS.
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Emerging research suggests that perceiving injustice can compound the suffering of chronic pain, while perceiving justice serves as a positive psychological resource in this context. However, little more is currently known about the function of justice beliefs, particularly in the context of acute pain. The present study undertook this investigation, using cold pressor methodology to investigate whether trusting in the fairness of the world would help someone to cope with short-term pain. ⋯ The observed gender differences may be attributed to gender variations in cognitive appraisals of the task. Overall, while perceived injustice may be undesirable and a potential target for intervention, perceived justice is not necessarily a desired cognition in pain. Research is needed to replicate and extend this emerging research.