The British journal of surgery
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Multicenter Study
Isolated limb perfusion using tumour necrosis factor α and melphalan in patients with advanced aggressive fibromatosis.
Aggressive fibromatoses (desmoid tumours) may be locally aggressive, but do not metastasize. Although a conservative approach is advocated for most patients, pain and functional impairment are indications for active treatment. Tumour necrosis factor (TNF) α and melphalan-based isolated limb perfusion (TM-ILP) is a limb-saving treatment modality for soft tissue tumours. This study reports the results of TM-ILP treatment in patients with aggressive fibromatosis. ⋯ TNF-α-based ILP is effective in patients with aggressive fibromatosis.
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Randomized Controlled Trial Comparative Study
Influence of visual force feedback on tissue handling in minimally invasive surgery.
Force feedback might improve surgical performance during minimally invasive surgery. This study sought to determine whether training with force feedback shortened the tissue-handling learning curve, and examined the influence of real-time visual feedback compared with postprocessing feedback. ⋯ The tissue-handling skills of medical students improved significantly when they were given force feedback of their performance. This effect was seen mainly during the knot-tying phase of the suturing task.
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Randomized Controlled Trial Comparative Study
Oncological outcome of malignant colonic obstruction in the Dutch Stent-In 2 trial.
The Stent-In 2 trial randomized patients with malignant colonic obstruction to emergency surgery or stent placement as a bridge to elective surgery. The aim of this study was to compare the oncological outcomes. ⋯ ISRCTN46462267 ( http://www.controlled-trials.com).
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Comparative Study Observational Study
Outcomes after implementing a tailored endoscopic step-up approach to walled-off necrosis in acute pancreatitis.
The aim of the study was to compare the outcomes of patients with pancreatic or peripancreatic walled-off necrosis by endoscopy using the conventional approach versus an algorithmic approach based on the collection size, location and stepwise response to intervention. ⋯ An algorithmic approach to pancreatic and peripancreatic walled-off necrosis, based on the collection size, location and stepwise response to intervention, resulted in an improved rate of treatment success compared with conventional endoscopic management.