The British journal of surgery
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Observational Study
Safety, productivity and predicted contribution of a surgical task-sharing programme in Sierra Leone.
Surgical task-sharing may be central to expanding the provision of surgical care in low-resource settings. The aims of this paper were to describe the set-up of a new surgical task-sharing training programme for associate clinicians and junior doctors in Sierra Leone, assess its productivity and safety, and estimate its future role in contributing to surgical volume. ⋯ SACHOs rapidly and safely achieved substantial increases in surgical volume in Sierra Leone.
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Oesophageal adenocarcinoma (OAC) is a highly aggressive malignancy with poor survival, which is highly variable amongst patients with comparable conventional prognosticators. Therefore molecular biomarkers are urgently needed to improve the prediction of survival in these patients. SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor involved in embryonal development of the gastrointestinal tract as well as in carcinogenesis. The purpose of this study was to see whether SOX2 expression is associated with survival in patients with OAC. ⋯ SOX2 is an independent prognostic factor for long-term survival in OAC, especially in patients with stage I OAC.