The British journal of surgery
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Multicenter Study Observational Study
Outcomes of patients receiving a massive transfusion for major trauma.
The benefits of high transfusion ratios (plasma to red blood cells and platelets to red blood cells) on survival in injured patients who receive massive transfusions remain uncertain. This study aimed to assess the association between transfusion ratios and adverse events and survival in patients undergoing massive transfusion for major trauma. ⋯ In this study, transfusion strategies with high plasma to red blood cell and platelet to red blood cell ratios did not have survival benefits, but were associated with an increase in adverse events.
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Multicenter Study
Omission of surgery in older women with early breast cancer has an adverse impact on breast cancer-specific survival.
Primary endocrine therapy is used as an alternative to surgery in up to 40 per cent of women with early breast cancer aged over 70 years in the UK. This study investigated the impact of surgery versus primary endocrine therapy on breast cancer-specific survival (BCSS) in older women. ⋯ BCSS in older women with ER-positive disease is worse if surgery is omitted. This treatment choice may contribute to inferior cancer outcomes. Selection for surgery on the basis of predicted life expectancy may permit choice of women for whom surgery confers little benefit.
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Multicenter Study Observational Study
Oncological outcome after MRI-based selection for neoadjuvant chemoradiotherapy in the OCUM Rectal Cancer Trial.
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Multicenter Study
Prognostic value of pathological node status after neoadjuvant radiotherapy for rectal cancer.
The prognostic value of pathological lymph node status following neoadjuvant radiotherapy (ypN) remains unclear. This study was designed to determine whether ypN status predicted overall survival. ⋯ Both ypT and ypN status is of prognostic significance following neoadjuvant therapy for rectal cancer.