The British journal of surgery
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Historical Article
Anatomy lesson of the brain and cerebral membranes captured on canvas by Rembrandt in 1656.
The Anatomy Lesson of Jan Deijman, painted by Rembrandt in 1656, is one of the most extraordinary historical paintings recording an anatomical demonstration of the brain and the cerebral membranes. This painting belongs to the series of group portraits made for the Amsterdam Guild of Surgeons in the 17th and 18th centuries. Unfortunately, the painting was seriously damaged by a fire in the boardroom of the Surgeons' Guild in 1723. ⋯ The abdominal organs have been removed, and the brain and cerebral membranes are about to be dissected. The nature of the depicted anatomical structures was assessed recently. This revealed that, by showing the falx cerebri, Rembrandt at the same time probably concealed a memento mori message in his masterpiece.
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The aim of this study was to monitor the effect of humidified-warm carbon dioxide (HWCO2 ) delivered into the open abdomen of mice, simulating laparotomy. ⋯ HWCO2 diffusion into the abdomen in the context of open surgery afforded tissue protection and accelerated tissue repair in mice, while preserving normothermia. Surgical relevance Damage to the peritoneum always occurs during open abdominal surgery, by exposure to desiccating air and by mechanical trauma/damage owing to the surgical intervention. Previous experimental studies showed that humidified-warm carbon dioxide (HWCO2 ) reduced peritoneal damage during laparoscopic insufflation. Additionally, this intervention decreased experimental peritoneal carcinomatosis compared with the use of conventional dry-cold carbon dioxide. In the present experimental study, the simple delivery of HWCO2 into the open abdomen reduced the amount of cellular damage and inflammation, and accelerated tissue repair. Sites of surgical intervention serve as ideal locations for cancer cell adhesion and subsequent tumour formation, but this was not changed measurably by the delivery of HWCO2 .