The British journal of surgery
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Randomized Controlled Trial Multicenter Study
A randomized clinical trial comparing early patient-reported pain after open anterior mesh repair versus totally extraperitoneal repair of inguinal hernia.
This was a prospective, multicentre, non-blinded, randomized clinical trial involving two parallel groups of patients. ⋯ TEP inguinal hernia repair is associated with less early postoperative pain compared to the open glue mesh fixation technique.
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Colorectal cancer (CRC) is the second most common solid organ cancer. Traditional treatment is with surgery and chemotherapy. Immunotherapy has recently emerged as a neoadjuvant therapy that could change treatment strategy in both primary resectable and metastatic CRC. ⋯ Early data on the effect of immunotherapy in CRC provide new strategic thinking of treatment options in CRC for both early-stage and advanced disease, with prospects for new trials.
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Current evidence for the effects of radiotherapy (RT) on implant-based immediate breast reconstruction (IBR) is limited by short follow-up and lack of patient-reported outcomes (PROs). It is central to integrate long-term comprehensive outcome data into the preoperative decision-making process. The aim of the present study was to determine long-term surgical outcomes and PROs in relation to RT after implant-based IBR. ⋯ Although RT was significantly associated with higher implant removal rates, PROs remained stable over 8 years despite irradiation.