The British journal of surgery
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Permanent hypoparathyroidism remains the most common adverse outcome after total thyroidectomy, but long-term effects of hypoparathyroidism are unknown. The aim was to investigate mortality in patients with permanent hypoparathyroidism after total thyroidectomy. ⋯ Permanent hypoparathyroidism after total thyroidectomy for benign disease is common and associated with an increased risk of death.
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The Anatomy Lesson of Willem Röell, painted by Cornelis Troost in 1728, should be considered a group portrait of the Amsterdam Guild of Surgeons. Professor Röell, praelector anatomiae (lecturer in anatomy) of the Surgeons' Guild, was portrayed while performing an anatomical dissection of the knee joint in the corpse of an elderly man. The three surgeons in the painting, dressed in fashionable suits, held important positions as governors of the Guild. ⋯ These works of art were painted to commemorate the praelector anatomiae, governors and surgeons of the Guild. Today, this painting is on display in the Amsterdam Museum in Amsterdam, The Netherlands. Read more about the stories behind this masterpiece in an essay online.
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In patients with multiple endocrine neoplasia type 2 (MEN2) syndrome, genetic testing offers early diagnosis, stratifies the risk of developing medullary thyroid cancer (MTC) and informs the timing of thyroidectomy. The efficacy of treatment, which depends on timely and safe surgery, is not well established. ⋯ Late genetic testing may preclude age-appropriate surgery, increasing the risk of operating when MTC has already developed. Early genetic testing and age-appropriate surgery may help avoid unnecessary lymphadenectomy and improve outcomes.
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Observational Study
Mortality following surgery for trauma in an Indian trauma cohort.
India accounts for 20 per cent of worldwide trauma mortality. Little is known about the quality of trauma surgery in an Indian setting. The aim of this study was to estimate the overall perioperative mortality rate, and to assess the association between type of acute surgical intervention and perioperative mortality among adult patients treated for trauma in an urban Indian setting. ⋯ In this study of surgery in an Indian trauma cohort, there was an excess of late perioperative deaths. Mortality differed significantly according to the type of surgery being undertaken.
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Increasing evidence has indicated an association between immune infiltration in gastric cancer and clinical outcome. However, reliable prognostic signatures, based on systematic assessments of the immune landscape inferred from bulk tumour transcriptomes, have not been established. The aim was to develop an immune signature, based on the cellular composition of the immune infiltrate inferred from bulk tumour transcriptomes, to improve the prognostic predictions of gastric cancer. ⋯ The proposed immunoscore represents a promising signature for estimating overall survival in patients with gastric cancer.