The British journal of surgery
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Randomized Controlled Trial
Randomized clinical trial comparing self-gripping mesh with a standard polypropylene mesh for open inguinal hernia repair.
The introduction of mesh for open inguinal hernia repair has reduced the rate of recurrence, allowing research to focus on prevention of postoperative pain. In an effort to reduce chronic pain, a semiresorbable, lighter and self-gripping mesh was developed. ⋯ NTR1212 (http://www.trialregister.nl).
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Multicenter Study
Multicentre study of neoadjuvant chemotherapy for stage I and II oesophageal cancer.
The benefit of neoadjuvant chemotherapy (NCT) for early-stage oesophageal cancer is unknown. The aim of this study was to assess whether NCT improves the outcome of patients with stage I or II disease. ⋯ NCT was associated with better overall and disease-free survival in patients with stage I or II oesophageal cancer, without increasing postoperative morbidity.
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The development of colorectal cancer is influenced by hormonal factors. Oophorectomy alters endogenous levels of sex hormones, but the effect on colorectal cancer risk is unclear. The aim of this cohort study was to examine colorectal cancer risk after oophorectomy for benign indications. ⋯ Colorectal cancer risk is increased after oophorectomy for benign indications.
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Liver resection for intermediate (Barcelona Clinic Liver Cancer (BCLC) stage B) hepatocellular carcinoma (HCC) remains controversial. This study attempted to demonstrate the effectiveness of preresection transarterial chemoembolization (TACE) as a selection criterion for BCLC-B HCC. ⋯ mRECIST may represent selection criterion for intermediate HCC for surgical treatment.
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Completeness of excision is the most important factor influencing local recurrence after breast-conserving surgery (BCS). The aim of this case-control study was to determine factors influencing incomplete excision in patients undergoing BCS. ⋯ Underestimation of tumour size by current imaging techniques is a major factor associated with incomplete excision in women undergoing BCS.