Critical care : the official journal of the Critical Care Forum
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Neutrophils use cell surface molecules to communicate with their external environment. These molecules are markers reflecting neutrophil development, activation status and cell function. They are also critically important in controlling neutrophil behavior. Targeting these cell surface molecules is an attractive approach in the treatment of neutrophil-mediated conditions.
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Malaria represents a medical emergency because it may rapidly progress to complications and death without prompt and appropriate treatment. Severe malaria is almost exclusively caused by Plasmodium falciparum. The incidence of imported malaria is increasing and the case fatality rate remains high despite progress in intensive care and antimalarial treatment. ⋯ Renal replacement therapy should be initiated early. Exchange blood transfusion has been suggested for the treatment of patients with severe malaria and high parasitemia. For early diagnosis, it is paramount to consider malaria in every febrile patient with a history of travel in an area endemic for malaria.
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Review Comparative Study
Pro/con clinical debate: Hydroxyethylstarches should be avoided in septic patients.