Critical care : the official journal of the Critical Care Forum
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Microbiota-driven interleukin-17 production provides immune protection against invasive candidiasis.
The intestinal microbiota plays a crucial role in human health, which could affect host immunity and the susceptibility to infectious diseases. However, the role of intestinal microbiota in the immunopathology of invasive candidiasis remains unknown. ⋯ Our data revealed that intestinal microbiota plays a protective role in invasive candidiasis by enhancing IL-17A production in our model system.