Critical care : the official journal of the Critical Care Forum
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Randomized Controlled Trial
Randomized controlled trial: neostigmine for intra-abdominal hypertension in acute pancreatitis.
Intra-abdominal hypertension (IAH) in acute pancreatitis (AP) is associated with deterioration in organ function. This trial aimed to assess the efficacy of neostigmine for IAH in patients with AP. ⋯ Neostigmine reduced IAP and promoted defecation in patients with AP and IAH. These results warrant a larger, placebo-controlled, double-blind phase III trial. Trial registration Clinical Trial No: NCT02543658 (registered August /27, 2015).