Neuromodulation : journal of the International Neuromodulation Society
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Objectives. To evaluate magnetic resonance imaging-related (MRI-related) heating for the VNS Therapy System at 1.5 and 3 tesla (T) using various device configurations and MRI conditions and to assess device function before and after MRI. Methods. The VNS Therapy System (pulse generator, Model 102; leads Models 300 and 302; Cyberonics, Inc., Houston, Tex, USA) underwent assessment of MRI-related heating at 1.5 and 3 T using different positioning configurations, leads, transmit radiofrequency (RF) coils (body and head), RF power levels, and scans on different body regions. The function of the VNS Therapy System was evaluated before and after scanning. ⋯ Conclusions. MRI-related heating was characterized for a variety of scenarios, identifying unsafe as well as safe conditions. Device function was unaffected by MRI procedures at 1.5 and 3 T. By following specific conditions, safety guidelines for the VNS Therapy System may be expanded beyond those currently indicated by the manufacturer.
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Objective. To evaluate the ability to relieve shoulder pain by implanting ceramic-case versions of radiofrequency microstimulators (RFM) in paralyzed shoulder muscles. Materials and Methods. A 66-year-old man, who had left-sided chronic hemiplegia due to a stroke five years previously, had developed shoulder subluxation resulting in pain. Two RFM devices were implanted, one next to the axillary nerve and one at the motor point of the middle deltoid muscle. ⋯ Results. During the treatment period of six months of stimulation, the patient's pain had reduced from 70 to 0 on the VAS. At six months after completion of the treatment, pain relief and effective evoked muscle contraction have remained. Conclusion. Although these results suggest that the feasibility of using RFM devices implanted both epineurally to the axillary nerve and next to the muscle motor point in this one patient, to relieve pain and elicit contraction, further investigation is needed to demonstrate the clinical feasibility of using RFMs for treating poststroke shoulder pain.
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Objectives. Traditional deep brain stimulation (DBS) at the subthalamic nucleus (STN) has proved to be efficacious on core Parkinsonian symptoms. However, very disabling l-dopa-induced abnormal involuntary movements (AIMs) and axial signs are slightly affected, suggesting that we target less conventional targets. Our candidates for DBS were the globus pallidus internus (GPi) plus the intralaminar thalamic complex (Pf or CM), given its extensive functional links with basal ganglia nuclei. ⋯ CM-Pf activation was only slightly effective in reducing rigidity and akinesia, but more efficacious on freezing. Not surprisingly, AIMs were peculiarly decreased by the activation of the permanent electro-catheter in the posteroventral GPi. Conclusions. These findings confirm that, in selected patients, it is conceivable to target structures other than the conventional STN in order to maximize clinical benefit.