Regional anesthesia and pain medicine
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Reg Anesth Pain Med · Jan 2002
Case ReportsIntrathecal baclofen: a useful agent in the treatment of well-established complex regional pain syndrome.
We present 2 case reports that illustrate that chronic intrathecal (IT) baclofen administration may be efficacious in treating patients with long-standing complex regional pain syndrome, type I (CRPS I) who have failed treatment with multiple drugs and procedures. ⋯ IT baclofen appears to be an option for patients with intractable CRPS who have failed other modalities, including IT morphine.
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Reg Anesth Pain Med · Jan 2002
Intrathecal lidocaine causes posterior root axonal degeneration near entry into the spinal cord in rats.
The neurotoxicity of lidocaine is not fully understood, and the primary lesion of lidocaine-induced spinal neurotoxicity has not been defined. Here we examine the effects of various concentrations of intrathecally administered lidocaine. ⋯ Our results suggest that spinal lidocaine neurotoxicity after supra-clinical concentrations of lidocaine is limited initially to the posterior roots at their entry to the spinal cord, and the extent and severity of the lesions are closely associated with lidocaine concentration. Unlike severe lesions in rats injected with 20% lidocaine, mild lesions caused by lower concentrations may not manifest neurofunctional deficits.
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Reg Anesth Pain Med · Jan 2002
Randomized Controlled Trial Clinical TrialHypnosis increases heat detection and heat pain thresholds in healthy volunteers.
Hypnosis has been reported to induce analgesia and to facilitate anesthesia. To date, hypnotic-induced analgesia has had little explanation and it has even been questioned. The current study was thus designed to investigate the effect of hypnotic suggestion on thermal-detection thresholds, heat pain, and heat-pain tolerance thresholds. ⋯ These results indicate that hypnosis may partly impair the detection of A delta and C fibers stimulation, potentially explaining its analgesic effect.