Regional anesthesia and pain medicine
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Reg Anesth Pain Med · Jan 2006
Historical ArticleThe American Society of Regional Anesthesia: a concise history of the original group-its birth, growth, and eventual dissolution.
The history of the original American Society of the Regional Anesthesia is presented-its birth, growth, and eventual dissolution. Reasons for its dissolution are discussed.
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Reg Anesth Pain Med · Jan 2006
Historical ArticleWhite Knight: ASRA, ASA, and the formation of the ABA.
The original American Society of Regional Anesthesia (1924-1940) was instrumental in the formation of the American Board of Anesthesiology, whereupon competence in anesthesiology was placed on the same footing as every other specialty practice in the United States.
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Reg Anesth Pain Med · Jan 2006
Efficacy of lidocaine or bupivacaine combined with ephedrine in rat sciatic nerve block.
The adrenergic drug ephedrine inhibits Na(+) current in cultured cells expressing Na(+) channels and provides dose-dependent reversible rat sciatic nerve blockade. The dosage required for peripheral nerve blockade in humans would cause unacceptable cardiovascular side effects. We therefore hypothesized that either lidocaine or bupivacaine would show synergy with ephedrine in a rat sciatic nerve block model, allowing a dose reduction and limiting side effects while improving efficacy. ⋯ A combination of ephedrine with either lidocaine or bupivacaine is unlikely to allow a significant dose reduction because of a lack of synergy. Furthermore, the cardiovascular side effects will limit the maximal tolerable dosage of ephedrine.