Regional anesthesia and pain medicine
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Reg Anesth Pain Med · Sep 2006
Ultrastructure of canine meninges after repeated epidural injection of S(+)-ketamine.
The safety of ketamine when administered by the spinal route must be confirmed in various animal species before it is approved for use in humans. This study evaluates the ultrastructure of canine meninges after repeated doses of epidural S(+)-ketamine. ⋯ Repeated doses of epidural S(+)-ketamine 5%, 1 mg/kg, twice a day for 10 days was not associated to cellular alterations in canine meninges.