Regional anesthesia and pain medicine
-
Reg Anesth Pain Med · Jan 2012
Comparative StudyCutaneous analgesia and systemic toxicity of carbetapentane and caramiphen in rats.
Caramiphen produces spinal anesthesia; caramiphen and carbetapentane have never been tested as infiltrative cutaneous analgesic. The aim of this study was to compare cutaneous analgesia of caramiphen and carbetapentane with bupivacaine and evaluated their central nervous system and cardiovascular toxicity. ⋯ Carbetapentane and caramiphen were similar to bupivacaine at producing durations of cutaneous analgesia but were less likely than bupivacaine to induce central nervous system and cardiovascular systemic toxicity.