Regional anesthesia and pain medicine
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Reg Anesth Pain Med · Feb 2020
Sonic hedgehog signaling pathway promotes pancreatic cancer pain via nerve growth factor.
Many patients with pancreatic cancer (PC) suffer from abdominal pain and back pain. However, the cause of pain associated with PC is largely unclear. In this study, we tested the potential influence of the sonic hedgehog (sHH) signaling pathway on PC pain. ⋯ Our results demonstrate that PC pain originates from the sHH signaling pathway, and NGF mediates the pain mechanism via regulating SP and CGRP.