Regional anesthesia and pain medicine
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Reg Anesth Pain Med · Mar 2012
Randomized Controlled Trial Multicenter Study Comparative StudyBupivacaine extended-release liposome injection exhibits a favorable cardiac safety profile.
Bupivacaine extended-release liposome injection is an investigational local analgesic intended for use in postsurgical pain management. In recognition of the incompletely characterized association of bupivacaine use and cardiac effects, this article reviews the cardiac safety profile of this novel formulation of bupivacaine. ⋯ A focused assessment of ECG data from a phase 2 study and cardiac findings/AEs data from other studies in the bupivacaine extended-release development program did not reveal any cardiac safety issues.
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Reg Anesth Pain Med · Mar 2012
Randomized Controlled Trial Comparative StudyBilateral transversus abdominis plane block does not decrease postoperative pain after laparoscopic cholecystectomy when compared with local anesthetic infiltration of trocar insertion sites.
Transversus abdominis plane (TAP) block has been shown to reduce pain and analgesic requirements after abdominal surgery. Our hypothesis was that bilateral TAP blocks decrease pain after laparoscopic cholecystectomy when compared with local anesthetic infiltration of trocar insertion sites. ⋯ Bilateral ultrasound-guided TAP block is equivalent to local anesthetic infiltration of trocar insertion sites for overall postoperative pain in a heterogeneous group of patients undergoing laparoscopic cholecystectomy.
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Reg Anesth Pain Med · Mar 2012
Randomized Controlled TrialThe analgesic effects of a bilateral sternal infusion of ropivacaine after cardiac surgery.
The aim of this study was to assess the effects of a continuous postoperative administration of local anesthetic through 2 catheters placed deeply under fascia at the lateral edges of the sternum, close to the emergence of the intercostal nerves. We focused on pain during mobilization, as this aspect is likely to interact with postoperative morbidity. ⋯ This technique may find a role within the framework of multimodal analgesia after sternotomy, although further confirmatory studies are needed.
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Reg Anesth Pain Med · Mar 2012
Cervical medial branch block: a novel technique using ultrasound guidance.
Cervical medial branch blocks are commonly performed for the diagnosis and treatment of head, neck, and shoulder pain. Intermittent fluoroscopy is widely used for needle positioning and visualization of contrast distribution before medication injection. The purpose of this study was to examine the use of ultrasound as an alternative imaging technique to block the third occipital nerve and the C3 to C6 medial branches. ⋯ Ultrasound guidance offers a reliable alternative to fluoroscopy for third occipital nerve and C3-C6 cervical medial branch blocks. Further studies are required to validate the clinical efficacy of our technique.