Journal of clinical monitoring and computing
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J Clin Monit Comput · Dec 1998
Comparative Study Clinical TrialMeasurement of blood concentration of indocyanine green by pulse dye densitometry--comparison with the conventional spectrophotometric method.
Pulse dye densitometry (PDD) uses two wavelengths (805 and 890 nm) in association with pulse oximetry to compute the arterial blood concentration ratio of indocyanine green (ICG) to hemoglobin (Hb). When Hb is measured in the usual way, this permits the PDD to compute cardiac output, plasma or blood volume, and liver blood flow following an intravenous injection of ICG. In this study, we evaluate the accuracy of the PDD calculation of dye concentration by comparing it with measurement of the dye concentration in blood (Cb) measured by the spectrophotometric cuvette method during dye clearance in patients. ⋯ These errors are of similar size to those associated with thermal cardiac output measurement, suggesting that PDD should be valuable clinically as a noninvasive tool especially since it provides values for blood volume and liver blood flow.