Surgical infections
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Surgical infections · Aug 2011
Liver X receptor protects against liver injury in sepsis caused by rodent cecal ligation and puncture.
Liver X receptor (LXR) is a transcription factor of the nuclear receptor family, regulating genes involved in metabolism, inflammation, and apoptosis. In the present investigation, we examined the role of LXR in organ injury and systemic inflammation in rodent models of polymicrobial peritonitis caused by cecal ligation and puncture (CLP). ⋯ Collectively, these results argue in favor of a role for LXRα in protection against liver injury in experimental sepsis induced by CLP.