Surgical infections
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Surgical infections · Jan 2004
Comparative StudyCauses and consequences of fever complicating critical surgical illness.
Fever may have malign consequences in the postoperative period. This study was performed to determine the causes and consequences of fever in critically ill surgical patients. The specific hypothesis tested is that postoperative fever is associated with adverse clinical outcomes, including increased organ dysfunction and risk of death. ⋯ Postoperative fever is deleterious to critically ill patients. The magnitude of fever is a determinant of mortality, whereas an infectious etiology of fever may not be. The impacts of nosocomial infection and suppression of fever on critically surgical patients deserve further study.
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Surgical infections · Jan 2004
Review Comparative StudyNew strategies to improve outcomes in the surgical intensive care unit.
Over the last half-decade, substantial breakthroughs have taken place in terms of routine therapy of critically ill patients. The combination of these strategies has the potential to result in improvement in the overall outcomes for patients in intensive care units. ⋯ Appropriate incorporation of these strategies into everyday practice will likely result in improvements in the care of critically ill surgical patients.
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Surgical infections · Jan 2004
Randomized Controlled Trial Comparative Study Clinical TrialSafety of drotrecogin alfa (activated) in surgical patients with severe sepsis.
We conducted a retrospective evaluation of the overall safety of drotrecogin alfa (activated) in surgical patients with severe sepsis enrolled in PROWESS. ⋯ Although treatment of surgical patients with drotrecogin alfa (activated) for severe sepsis is associated with a higher incidence of serious bleeding and subsequent treatment- emergent bleeding events, the magnitude of this increase is small and clinically acceptable.
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Surgical infections · Jan 2004
Review Case ReportsCryptococcal myositis and vasculitis: an unusual necrotizing soft tissue infection.
Cryptococcus neoformans var. neoformans is an opportunistic yeast that typically infects immunocompromised patients. ⋯ Cryptococcal soft tissue infection serves as a marker of disseminated cryptococcosis in immunocompromised hosts. Owing to its rarity as a cause of soft tissue infections, diagnosis is difficult and mortality is high.
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Surgical infections · Jan 2004
Comparative StudyStatic and dynamic assessment of biomarkers in surgical patients with severe sepsis.
Severe sepsis, defined as a systemic inflammatory response to infection associated with acute organ dysfunction, is common among surgical patients and is a major cause of morbidity and mortality. Severe sepsis has been associated with changes in inflammatory and hemostatic biomarkers. In patients undergoing surgical procedures there may be additional stimulation of cytokine release and activation of the coagulation system. The purpose of this study was to characterize the baseline differences in biomarkers between surgical and non-surgical patients. In addition, we assessed the dynamic changes in biomarkers and coagulation parameters in surgical patients with severe sepsis enrolled in PROWESS and treated with placebo or drotrecogin alfa (activated). ⋯ Surgical patients with severe sepsis appear to have a higher severity of illness at baseline as demonstrated by derangements in biomarkers and coagulation markers compared to non-surgical patients. Surgical patients treated with drotrecogin alfa (activated)showed reduced D-dimer concentrations and a more rapid increase in protein C concentrations during the infusion period.