Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
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A report is presented of a patient with tertiary syphilis of the skin with biologically false negative 19S-(IgM-)FTA-ABS-test. This possibility of failure in this otherwise highly reliable test for the detection of specific 19S-(IgM-)antibodies is still little known.
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Eight of 400 (2%) unselected dermatological patients showed an IgA deficiency in their serum. Two had a complete and four an isolated deficiency of serum IgA. In three patients the IgA deficiency was combined with a deficiency of another immunoglobulin (antibody deficiency syndrome), and twice with a cellular immunodeficiency. ⋯ Most patients with IgA deficiency had recurrent infections of the skin and mucous membranes, or the dermatoses were caused secondarily by an inflammatory process of the latter. In contrast to the deficiency of serum IgA the concentration of secretory IgA in the saliva was normal. The immunotherapy of serum IgA deficiency depended on the existence or absence of associated immunological disorders: in case of isolated IgA deficiency substitution with enriched IgA, in antibody deficiency syndrome with gamma globulin and in combined humoral and cellular immune deficiency with additional therapy with transfer factor.
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The imported tropical dermatoses include the various manifestations of dermal myiasis. Cases of the furuncular form of cutaneous myiasis are infrequently seen and occur much more seldom than creeping eruption. Nearly exclusively furuncular lesions appear after infestation with the larvae of Dermatobia hominis, the human botfly, in Central and South America and with the larvae of the tumbu-fly, Cordylobia anthropophaga, in tropical Africa. We had the opportunity to see a patient, who had acquired furuncular myiasis due to Dermatobia hominis in Bolivia and the emergence of his fully developed larvae.
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Principles, possibilities and limits of an immunotherapy of malignant melanoma are discussed. On account of the results of immunological investigations in melanoma patients and in animal models the immunogenicity of melanoma cells and the stage dependent immune reactivity of tumor bears seem to be certain. ⋯ Netherless these therapy trials are still in the state of clinical testing. Controlled long term studies of immunotherapy schedules under observation of the immune profile of the patients in vivo and in vitro are necessary in order to determine the place of immunotherapy within the range of oncological therapeutic possibilities.
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In a 56 year old patient with zoster in the thoracic segments 10 and 11 an abdominal hernia developed. The hernia was caused by peripheral motorial paresis.