Biomed Pap
-
Comparative Study
Influence of age and gender on the pharmacodynamic parameters of rocuronium during total intravenous anesthesia.
To compare the pharmacodynamics of 0.6 mg kg(-1) rocuronium in young and older patients of both genders during total intravenous anesthesia. ⋯ Females and older patients were more sensitive to rocuronium.
-
This study compares the outcomes of patients with high-risk acute myeloid leukemia (AML) who underwent allogeneic stem cell transplantation (SCT) after conditioning combining busulfan (16 mg/kg orally) and cyclophosphamide (120 mg/kg intravenously) (BU-CY) with those allografted after administration of fludarabine (150 mg/m(2) intravenously), busulfan (12 mg/kg orally) and thymoglobulin (6 mg/kg intravenously) (FLU-BU12-TG). ⋯ These pilot results demonstrate the efficacy of the new FLU-BU12-TG conditioning regimen in patients allografted for high-risk AML. This conditioning might become an alternative approach in patients at high risk of severe post-transplant complications after the standard BU-CY myeloablative regimen.
-
To determine the inter-observer reproducibility of 15 tests used for predicting difficult tracheal intubation (DI). ⋯ Best inter-rater agreement was found for the assessment of neck circumference while the highest discrepancies between raters were in goniometrically-measured mobility of the C-spine. Many of the pre-operative airway tests had only fair inter-observer reproducibility. This may be one reason why models for predicting difficult intubation are not universally reliable.
-
Randomized Controlled Trial Comparative Study
i-gel™ vs. AuraOnce™ laryngeal mask for general anaesthesia with controlled ventilation in paralyzed patients.
The i-gel™ and the AuraOnce™ laryngeal mask are supraglottic airway devices used for airway management during general anaesthesia. Both devices are cheap, disposable and widely used. They may be used with both spontaneous and controlled ventilation. This study compared differences in the seal and peak pressures, and postoperative complications in these devices when used in paralyzed patients under controlled ventilation. ⋯ First time insertions were 85.6% (i-gel) and 82% (AuraOnce) with overall success rates 96.3% (i-gel) and 94.2% (AuraOnce) (p=0.54). Average insertion times were 11.0 s (i-gel) and 11.6 s (AuraOnce) (p=0.19). Seal pressures were 30.4 cmH(2)O (i-gel) and 27.8 cmH(2)O (AuraOnce) (p=0.007). Peak pressures were 15.3 cmH(2)O (i-gel) and 15.6 cmH(2)O (AuraOnce) (p=0.57). Traumatic insertion occurred in 5.8% of i-gel™ and 2% of AuraOnce™ insertions. The overall incidence of postoperative complications was low, with the i-gel™ causing less sore throat and difficulty swallowing at 24h. Conclusion. Both devices provided effective seals for ventilation under positive pressure. I-gel™ may be a better alternative for the procedures with controlled ventilation because of higher seal pressures and lower incidence of sore throat postoperatively.
-
Randomized Controlled Trial
The effect of psychological intervention on perceived pain in children undergoing venipuncture.
The main objective of the study was to determine the effect of structured psychological intervention on the level of perceived pain in children undergoing venipuncture. A second goal was to investigate how pain behavior during venipuncture is affected by age, sex, previous number of venipunctures, the presence of parents during the procedure and reason for the venipuncture. ⋯ A significant difference in evaluated pain between the intervention group and the control group was found. The psychological intervention carried out by a nurse proved to lower pain levels from venipuncture as measured by the CHEOPS scale and evaluated using the self-report scale. A greater level of pain was found in children in the age group 5-7 years, in children where peripheral venous catheter was introduced and in children where the parents were present. Special consultation with the child one day before venipuncture reduced pain levels, especially in children below the age-category mentioned. Consultation should be part of the standard of care for children with indications for venipuncture.