Curr Ther Res Clin E
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Curr Ther Res Clin E · Sep 2012
The effect of transcutaneous electrical nerve stimulation on pain during venous cannulation.
The venous cannulation procedure was widely used in many clinical procedures; however, it is associated with pain or discomfort. ⋯ TENS may be a suitable option for reducing the pain intensity during venous cannulation. ClinicalTrials.gov identifier: NCT01607463.
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Curr Ther Res Clin E · Jun 2012
Effects of adding dexmedetomidine to levobupivacaine in axillary brachial plexus block.
Although several studies have described effects of dexmedetomidine on peripheral nerve blocks, to date there is limited knowledge available on the impact of dexmedetomidine adjunct to levobupivacaine in axillary brachial plexus block. ⋯ It was concluded in our study that adding dexmedetomidine to axillary brachial plexus block shortens sensory block onset time, increases the sensory and motor block duration and time to first analgesic use, and decreases total analgesic use with no side effects. ClinicalTrials.gov identifier ISRCTN67622282.
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Curr Ther Res Clin E · Feb 2012
Comparison of effects of low-flow sevoflurane and desflurane anesthesia on neutrophil and T-cell populations.
Numerous transient effects of anesthesia on postoperative immune status have been documented in the literature. ⋯ With use of the low-flow anesthesia technique, compared with desflurane, sevoflurane exerts minimal effects on neutrophil and T-cell populations, which supports our hypothesis.
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Curr Ther Res Clin E · Dec 2011
A simple contact heat experimental pain model for evaluation of analgesic agents in healthy volunteers.
Human experimental pain models help to understand the mechanism of the underlying clinical pain conditions and can be adopted to test analgesic efficacy of drugs used in the management of pain. In early phases, the clinical development of new analgesic agents is severely hindered due to lack of reliable sensitive tests for the experimental pain models. ⋯ The newly developed pain model produces a type of experimental pain that is responsive to analgesic effects of tramadol at clinically relevant doses. The model might be useful in early screening of new therapeutic agents before proceeding to expensive clinical trials in acute and chronic pain sufferers.
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Curr Ther Res Clin E · Oct 2011
N-Acetyl-l-Cysteine Attenuates Ischemia/Reperfusion Injury-Induced Allodynia and N-Methyl-d-Aspartate Receptor Activation in Rats.
Although reactive oxygen species (ROS) are believed to be involved in pathogenic mechanisms that underlie complex regional pain syndrome type I (CRPS-I), the role of ROS in the central mechanism of CRPS is not fully understood. ⋯ NAC, administered during the pre-reperfusion period, had a long-term antiallodynic effect through the attenuation of NMDA receptor phosphorylation, leading to central sensitization.