Emergencias
-
Multicenter Study
Scale to predict risk for refractory septic shock based on a hybrid approach using machine learning and regression modeling.
To develop a scale to predict refractory septic shock (SS) based on clinical variables recorded during initial evaluations of patients. ⋯ The RSSS had adequate diagnostic accuracy in multiple cohorts of patients diagnosed in the ED and ICU.
-
Patients with suspected infections account for 15% to 35% of hospital emergency department (ED) caseloads in Spain and Latin America. The main objective of this systematic review was to compare evidence supporting the safety and efficacy of early (3 hours after triage) vs deferred ($ 3-6 hours) antibiotic therapy prescribed in EDs for adults with serious infections or sepsis. Efficacy and improved clinical course were defined by reduced progression to septic shock and short- and long-term mortality. ⋯ Early initiation of antibiotic therapy, preferably within 3 hours of triage, can be recommended in cases of serious infection (sepsis or serious sepsis that do not meet the criteria for septic shock). In fact, based on a tendency for higher short- and long-term mortality associated with delay and a higher probability of developing septic shock with each hour of delay, therapy should start as soon as possible if infection is confirmed or suspected in the absence of an alternative diagnosis.