Eur J Trauma Emerg S
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Eur J Trauma Emerg S · Dec 2011
Effects on the ubiquitin proteasome system after closed soft-tissue trauma in rat skeletal muscle.
Previous studies have suggested that an increased catabolic stage of skeletal muscle in pathological situations is mainly a reflection of ubiquitin-proteasome system-controlled proteolysis. The proteolytic mechanisms that occur after local muscle trauma are poorly defined. We investigated the effects of closed soft-tissue trauma on ubiquitin-proteasome dependent protein breakdown in rats (n = 25). ⋯ Cellular levels of free and protein-conjugated ubiquitin were significantly elevated upon decreased proteolytic activity. Our data support an early-state anti-proteolytic role of the ubiquitin-proteasome pathway after local injury. This further implies that there is a yet-to-be elucidated complex regulatory mechanism of muscle regeneration that involves various proteolytic systems.
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Eur J Trauma Emerg S · Dec 2011
Health-related quality of life of trauma patients after intensive care: a 2-year follow-up study.
This study aimed to assess the health-related quality of life (HRQOL) in trauma patients 2 years after discharge from an intensive care unit (ICU) in Zunyi, China, and to investigate the possible determinants of HRQOL. ⋯ The HRQOL of a group of Chinese trauma patients after ICU treatment improved from 1 to 2 years after discharge. Age, sex, length of ICU stay, ISS, and existence of head injury were associated with physical or mental HRQOL after discharge. Further studies with more measurements and larger sample sizes are still warranted.
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Eur J Trauma Emerg S · Dec 2011
Long-term follow-up of blowout fractures of the orbital floor reconstructed with a polyglactin 910/PDS implant.
Resorbable alloplastic materials are used in many surgical applications. This retrospective study evaluated the clinical outcome after reconstruction of traumatic orbital floor defects using a polyglactin 910/PDS implant (Ethisorb™). ⋯ Reconstructive surgery of the orbit is one of the most demanding challenges in maxillofacial surgery. For traumatic defects of the orbital floor, reconstruction using a polyglactin 910/PDS implant (Ethisorb(™)) seems to be a reliable method for the repair of small-to-moderate defects.
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Eur J Trauma Emerg S · Dec 2011
Efficacy and safety of non-operative management of blunt liver trauma.
The liver is the most frequently affected organ during blunt abdominal trauma. Blunt liver trauma management has changed in the last two decades with the introduction of the computed tomography (CT) scan and non-operative management of stable patients. ⋯ Non-operative management is the treatment of choice for polytraumatized patients with blunt liver trauma who are hemodynamically stable. Non-operative management is an effective and safe treatment strategy. However, patients with an RTS score under 7.8 and other intra-abdominal non-liver injuries are at increased risk for an immediate surgical intervention.
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Eur J Trauma Emerg S · Dec 2011
Intramedullary femoral nailing through the trochanteric fossa versus greater trochanter tip: a randomized controlled study with in-depth functional outcome results.
In a level 1 university trauma center, an explorative randomized controlled study was performed to compare soft tissue damage and functional outcome after antegrade femoral nailing through a trochanteric fossa (also known as piriform fossa) entry point to a greater trochanter entry point in patients with a femoral shaft fracture. ⋯ Anatomical localization of the entry point seems to be important for per-operative soft tissue damage and subsequent functional impairment. However, the results of this study did not show appreciable differences between femoral nailing through the greater trochanter tip and nailing through the trochanteric fossa.