J Trauma
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Alcohol intoxication is associated with a high incidence of traumatic injury, particularly in the young healthy population. The impact of alcohol intoxication on the immediate pathophysiologic response to injury has not been closely examined. We hypothesized that acute alcohol intoxication would aggravate the immediate outcome from hemorrhagic shock by impairing homeostatic counterregulation to blood loss. ⋯ These results indicate marked alterations in the hemodynamic and metabolic responses to hemorrhagic shock by alcohol intoxication. Furthermore, our findings suggest that alcohol modulates the early proinflammatory responses to hemorrhagic shock. Taken together, these alterations in metabolic and inflammatory responses to hemorrhage are likely to impair immediate outcome and predispose to tissue injury.
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In a statistical outcome analysis covering 10 years, 554 patients with isolated head trauma were analyzed. The aim of this study was to combine clinical and computed tomographic characteristics in a prognostic scoring system determining outcome after head injury. ⋯ The presented scaling system allows a predictive value in mortality and morbidity to be determined for each patient suffering from brain trauma.