J Trauma
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Although brain cooling has been reported to be effective in improving the outcome after traumatic brain injury (TBI) in rats, the mechanisms of brain cooling-induced neuroprotective actions remain unclear. This study was to test whether angiogenesis and neurogenesis attenuating TBI could be brain cooling stimulated. ⋯ Brain cooling-stimulated angiogenesis and neurogenesis attenuated a fluid percussion TBI in rats.
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Ventilation of Acute Respiratory Distress Syndrome (ARDS) is a challenge, and there is definitely a need for lack of variations between delivered and set tidal volume (Vt). We have assessed the ability of the ventilator T-birdVS02 and LTV-1000 to deliver to a lung model with ARDS a set Vt at different simulated altitudes. ⋯ Clinicians involved in aerial evacuations must keep in mind the performance and limitations of their ventilator system.
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Hemorrhage is a frequent cause of morbidity and mortality, possibly complicated by volatile anesthetics administered during surgical emergencies. Because methylene blue (MB) was suggested to reduce bleeding, we reasoned that it may improve resuscitation. We used a rat model of controlled and uncontrolled hemorrhage with fluid resuscitation, aiming at high versus low mean arterial pressure (MAP) to assess the role of early MB injection on survival and the effects of different anesthetics on outcome. ⋯ MB improved parameters and survival rates after controlled and uncontrolled hemorrhage and fluid resuscitation, even in high MAP-resuscitated rats. KET seemed to be the best anesthetic choice among the four classic agents tested. The effects of balanced anesthesia and total intravenous anesthesia in similar conditions require additional studies.