J Trauma
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The management strategies for reconstruction of soft-tissue defects of the lower leg and the foot remain disputed. To date, no comprehensive studies have been reported on the saphenous perforator flaps in reconstructive surgery in patients with posttraumatic osteomyelitis. ⋯ The saphenous perforator flap is a sturdy flap with low short-term failure rates, also in high-risk patients. The success rate compares well with results of free flap transfers in the management of posttraumatic osteomyelitis. The saphenous flap is a feasible option for posttraumatic reconstructions of osteomyelitis, especially in low-resource settings.
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Rib fractures as a result of trauma are a relatively common injury. There is an increasing interest in the operative stabilization of these injuries. Absorbable fixation plates are an option for improved rib fracture treatment. The aim of this study was to review our plating failures and to create a numerical model of muscle forces on fractured ribs to identify the mechanism by which these rib fixations have failed. ⋯ This study indicates that the likely mode of failure of this absorbable plating system occurs on the posterior part of the rib, which correlates with the clinical failures seen.
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We have previously demonstrated that induction of profound hypothermia improves long-term survival in animal models of complex injuries/lethal hemorrhage. However, the precise mechanisms have not been well defined. The aim of this high-throughput study was to investigate the impact of profound hypothermia on gene expression profiles. ⋯ Profound hypothermia increases survival in a rodent model of hemorrhagic shock. In addition to decreasing tissue oxygen consumption, induction of hypothermia directly alters the expression profiles of key genes, with an overall up-regulation of pro-survival pathways and a down- regulation of metabolic pathways.