J Trauma
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There is evidence that complement components regulate cytokine production in osteoblastic cells, induce cell migration in mesenchymal stem cells, and play a regulatory role in normal enchondral bone formation. We proved the hypothesis that complement might be involved in bone healing after fracture. ⋯ Our in vitro and in vivo results demonstrated the presence of C5aR in bone forming osteoblasts and bone resorbing osteoclasts. It is suggested that C5aR might play a regulatory role in fracture healing in intramembranous and in enchondral ossification, one possible function being the regulation of cell recruitment.
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Traumatic pneumomediastinum secondary to blunt chest injury in children is concerning for potential life-threatening tracheobronchial, esophageal, or vascular thoracic injuries. These patients often undergo extensive radiologic evaluation and invasive testing due to the unclear risk of traumatic pneumomediastinum. ⋯ Tracheobronchial, esophageal, or vascular thoracic injuries were uncommon in children with traumatic pneumomediastinum and occurred in the setting of additional thoracic and other organ system injuries. Pneumomediastinum without radiographic or clinical evidence of other thoracic injuries may not routinely require further diagnostic testing.
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Wound excision is the standard treatment for firearm wounds. However, achieving a satisfactory curative effect is difficult because of the traumatic mechanism of high-velocity projectiles. We propose a new therapy by using topical bromelain as a supplement to wound incision for the debridement of firearm wounds. We clarified the debriding effect of bromelain on firearm wounds in pigs. ⋯ Bromelain is effective in the debridement of uncomplicated firearm wounds if used as a supplement to simple wound incision. This new therapy shows notable advantages over conventional surgical debridement as it greatly simplifies the procedures.