J Trauma
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Clinical Trial Controlled Clinical Trial
The impact of hypoxia and hyperventilation on outcome after paramedic rapid sequence intubation of severely head-injured patients.
An increase in mortality has been documented in association with paramedic rapid sequence intubation (RSI) of severely head-injured patients. This analysis explores the impact of hypoxia and hyperventilation on outcome. ⋯ Hyperventilation and severe hypoxia during paramedic RSI are associated with an increase in mortality.
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Investigations were performed to determine whether poly-N-acetyl glucosamine (p-GlcNAc) induces hemostasis by the activation of platelets. ⋯ Poly-N-acetyl glucosamine fiber material promotes hemostasis by the activation of platelets.
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Comparative Study
Diagnostic utility of sublingual PCO2 for detecting hemorrhage in penetrating trauma patients.
Hemorrhage results in early compromise of splanchnic circulation. Studies have shown that sublingual Pco2 (SLCO2) correlates with gut perfusion. We tested SLCO2's ability to detect hemorrhage. We compared SLCO2 with arterial base deficit (BD) and lactate (LAC). ⋯ SLCO2 differentiated blood loss groups. SLCO2 may be useful in triage of penetrating trauma patients.
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Case Reports
The applicability of a computer model for predicting head injury incurred during actual motor vehicle collisions.
Head injury is a significant cause of both morbidity and mortality. Motor vehicle collisions (MVCs) are the most common source of head injury in the United States. No studies have conclusively determined the applicability of computer models for accurate prediction of head injuries sustained in actual MVCs. This study sought to determine the applicability of such models for predicting head injuries sustained by MVC occupants. ⋯ Although computer modeling accurately simulates experimental crash tests, it may not be applicable for predicting head injury in actual MVCs. Many complicating factors surrounding actual MVCs make accurate computer modeling difficult. Future modeling efforts should consider variables such as age of the occupant and should account for a wider variety of crash scenarios.
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Comparative Study
Comparison of poly-N-acetyl glucosamine with commercially available topical hemostats for achieving hemostasis in coagulopathic models of splenic hemorrhage.
The hemostatic quality of the poly-N-acetyl glucosamine (p-GlcNAc) patch was compared with a fibrin sealant, fibrin bandage, and cellulose patch. ⋯ Poly-N-acetyl glucosamine was effective at controlling bleeding in animals with experimentally induced or genetic coagulopathic disorders.