J Trauma
-
The purpose of this study was to determine the incidence of acute lung injury (ALI) in trauma patients with severe traumatic brain injury (TBI), to evaluate the impact of ALI on mortality and neurologic outcome after severe traumatic brain injury (TBI), and to identify whether the development of ALI correlates with the severity of TBI. ⋯ The development of ALI is a critical independent factor affecting mortality in patients suffering traumatic brain injury and is associated with a worse long-term neurologic outcome in survivors. The risk of developing ALI is not associated with specific anatomic lesions diagnosed by cranial CT scanning.
-
Many management schemes have incorporated mandatory head computed tomography (HCT) to evaluate a patient sustaining blunt head trauma with a history of loss of consciousness (LOC). Commonly, this is despite physical examination findings warranting such a workup. This study is intended to better identify the significance of selective criteria, a set of constitutional signs and symptoms (CSS) for head injury, to screen patients sustaining blunt head trauma and LOC. ⋯ The liberal use of HCT in patients without CSS for head injury did not influence patient care, with no increase in morbidity or mortality. These results suggest that LOC alone is not predictive of significant head injury and is not an absolute indications for HCT. More objective criteria, such as CSS, should be used before initiating a costly workup where further diagnostic and therapeutic intervention is unlikely after mild head injury.
-
Adenosine A2a receptor stimulation can increase coronary perfusion and also reduce leukocyte-mediated inflammatory responses in some conditions. Hextend is a novel colloid solution that may have antioxidant properties. All these actions might be beneficial after severe chest trauma, but have never been investigated. To fill these gaps, this study evaluated the therapeutic potential of a novel adenosine A2a agonist during fluid resuscitation from severe chest trauma with either standard-of-care crystalloid or Hextend. ⋯ Hextend reduced the volume for initial resuscitation, which may offer logistical advantages in prehospital field conditions or whenever there is limited medical resources or prolonged transport times; ATL-146e improved early cardiac performance without causing hypotension or bradycardia; when administered 25 to 30 minutes after injury, neither Hextend nor ATL-146e altered inflammatory changes in pulmonary Mphis or infiltrating PMNs; and further studies are needed to determine whether these short-term benefits correlate with long-term outcome.