J Invest Allerg Clin
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J Invest Allerg Clin · Jan 2013
IL-4 gene polymorphisms and their association with atopic asthma and allergic rhinitis in Pakistani patients.
Interleukin (IL) 4 is a cytokine that mediates allergic responses. Different single nucleotide polymorphisms (SNPs) can influence the immune response mediated by cytokines. The aim of the present study was to investigate the possible association between IL-4 polymorphisms and allergic rhinitis and atopic asthma. ⋯ rs2243250 and rs2227284 are significantly associated with asthma and allergic rhinitis. The results of this study indicate that in addition to environmental factors, genetic risk factors also play an important role in the development of atopic respiratory diseases.