American journal of veterinary research
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Clinical Trial
Effect of one-lung ventilation on oxygen delivery in anesthetized dogs with an open thoracic cavity.
To evaluate effects of one-lung ventilation on oxygen delivery in anesthetized dogs with an open thoracic cavity. ⋯ One-lung ventilation affected gas exchange and hemodynamic function, although oxygen delivery in clinically normal dogs was not affected during a period with an open thoracic cavity. One-lung ventilation can be used safely in healthy dogs with an open thoracic cavity during surgery.
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Randomized Controlled Trial Clinical Trial
Effect of medetomidine administration on bispectral index measurements in dogs during anesthesia with isoflurane.
To determine the relationship between bispectral index (BIS) and minimum alveolar concentration (MAC) multiples of isoflurane after IM injection of medetomidine or saline (0.9% NaCl) solution in anesthetized dogs. ⋯ BIS monitoring in dogs anesthetized with isoflurane has a predictive value in regard to degree of CNS depression. During isoflurane anesthesia, our results support a MAC-reducing effect of medetomidine.
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To determine the hemodynamic effects of nitrous oxide in isoflurane-anesthetized cats. ⋯ Administration of 70% nitrous oxide to isoflurane-anesthetized cats resulted in improved arterial pressure, which was related to a vasoconstrictive effect.
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To investigate whether volumetric capnography indices could be used to differentiate between horses without recurrent airway obstruction (RAO) and horses with RAO that were in clinical remission or that had clinically apparent RAO. ⋯ Ratios of VD(Bohr) to VT and VD(phys) to VT as well as an index of effective CO2 elimination were sufficiently sensitive measures to distinguish between healthy horses and horses with RAO in remission. To optimize the ability of volumetric capnography indices to differentiate among horses in heterogeneous populations, it is important to account for effects of age and specific use of the horses.
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Randomized Controlled Trial Clinical Trial
Interactions of morphine and isoflurane in horses.
To quantitate dose- and time-related magnitudes of interactive effects of morphine (MOR) and isoflurane (ISO) in horses and to characterize pharmacokinetics of MOR in plasma and the ventilatory response to MOR during administration of ISO. ⋯ Our results do not support routine clinical use of MOR administered IV at dosages of 0.25 or 2.0 mg/kg as an adjuvant to anesthesia in horses administered ISO.