American journal of veterinary research
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To develop and validate a population pharmacokinetic model for gentamicin in horses, using retrospective clinical data. ⋯ Population pharmacokinetics can be used to design first-dosage regimens according to the clinical characteristics of individual animals. Population pharmacokinetic models could also be included in Bayesian forecasting strategies to improve plasma concentration predictions in individual patients.
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To evaluate the effect on intramuscular blood flow (IMBF) and hemodynamic variables of 4 antihypotensive agents given during anesthesia. ⋯ Of the agents investigated, dobutamine proved the most consistent in improving IMBF.
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Comparative Study
Comparison of anion gap and strong ion gap as predictors of unmeasured strong ion concentration in plasma and serum from horses.
To compare the accuracy of anion gap (AG) and strong ion gap (SIG) for predicting unmeasured strong ion concentration in plasma and serum from horses. ⋯ Anion gap and SIG can be used to predict plasma lactate concentration in horses. AG is accurate and clinically useful for estimating unmeasured strong ion concentration in horses with total protein concentrations within or slightly outside reference range, whereas SIG is more accurate in horses with markedly abnormal total protein concentrations and those of various ages and with various concentrations of albumin, globulin, and phosphate.
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Comparative Study
Cardiopulmonary effects of propofol and a medetomidine-midazolam-ketamine combination in mallard ducks.
To compare safety of propofol with a medetomidine-midazolam-ketamine (MMK) combination as an anesthetic agent in mallard ducks. ⋯ The MMK combination in unsafe for use in ducks. Ducks can be anesthetized safely with propofol but should be monitored and ventilated artificially.
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To determine the concentrations of sevoflurane and compound A (a degradation product of sevoflurane) in the anesthetic circuit when sevoflurane was delivered with an in-circuit vaporizer, and to determine the cardiorespiratory effects of sevoflurane in dogs. ⋯ Results suggested that sevoflurane can be administered to nonsurgically stimulated dogs, using an in-circuit vaporizer and low (< 15 ml/kg/min) oxygen flow rates, without causing significant cardiorespiratory depression or clinically important concentrations of compound A.