Hepato Gastroenterol
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Hepato Gastroenterol · May 2008
COMT gene val158met polymorphism in patients with dyspeptic symptoms.
The role of genetics in the susceptibility to functional dyspepsia (FD) is unclear. Catechol-O-methyltransferase (COMT) has been an important enzyme in brain gut axis and pain sensitivity. Polymorphism in codon 158 of the COMT gene influences its activity. This study aimed to clarify the association between COMT polymorphism and dyspepsia in a Japanese population. ⋯ The data suggest that the COMT genotype seems to influence the susceptibility of dyspepsia when it interacts with gender and age. The role of genetics in the development of dyspepsia needs to further evaluation.
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Hepato Gastroenterol · May 2008
Hepatectomy and pancreatectomy with combined vascular resection in patients with hepato-biliary and pancreas diseases at a single cancer institute.
In advanced cancers of hepatobiliary and pancreatic lesions, major vascular resection and reconstruction are necessary to accomplish curative resection, which may provide better patient outcomes. ⋯ Complete surgical resection (R0) combined with main vascular resection could be safely performed in many patients with disease of the hepatobiliary and pancreas, which achieved longer survival in some patients even in the advanced stage.
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Hepato Gastroenterol · May 2008
Comparative StudyThe use of different diagnostic modalities in diagnosing fistula-in-ano.
In this study, a comparison was made of the accuracy and clinical usefulness of clinical investigation, fistulography, and endorectal ultrasound with and without hydrogen peroxide in preoperative classification of the fistula-in-ano. ⋯ In this study, endorectal ultrasound with H2O2 was the most accurate diagnostic modality in the preoperative assessment of the fistula-in-ano. As it can provide valuable information that can influence the type of operative procedure, and because it is relatively cheap and available in almost all hospitals, it should be used prior to operative treatment in all patients with a fistula-in-ano.
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Hepato Gastroenterol · Mar 2008
ReviewPostoperative hemorrhage after major pancreatobiliary surgery: an update.
In recent years, mortality associated with pancreaticoduodenectomy has come down to less than 5% but morbidity still remains high. Pancreatic fistula is one of the most common complications following pancreaticoduodenectomy. Postpancreatectomy hemorrhage is a rare but disastrous complication and associated with poor outcome. ⋯ Delayed hemorrhage has more complex pathophysiology and requires a multimodality approach for its management. In this paper, we review the recent articles related to postoperative hemorrhage after major pancreatobiliary surgery. Here we discuss the incidence, cause, investigations and management of early and late postoperative hemorrhage.
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Hepato Gastroenterol · Mar 2008
Strong association between frequency of intermittent inflow occlusion and transient increase in serum liver enzymes after hepatic resection.
Although significantly higher serum levels of liver transaminases are commonly observed after hepatic resection, the factors responsible for the increase and the association between the increase and the postoperative course remain unclear. ⋯ The frequency of intermittent inflow occlusion is the only factor that affects the postoperative enzyme elevation.