Minerva anestesiologica
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Minerva anestesiologica · Jul 2005
Clinical TrialTransdermal buprenorphine combined with spinal morphine and naropine for pain relief in chronic peripheral vasculopathy.
of this study was to evaluate the effectiveness and the safety of the association of buprenorphine transdermal delivery system (TDS) (Transtec TDS) and peridural infusion of morphine and naropine, for the control of ischemic pain in patients suffering from peripheral arteriopathy. The administration of an opioid, pure agonist, as morphine, with a partial agonist opioid, as the buprenorphine, was used. Buprenorphine has shown a higher liposolubility in supraspinal districts, while the morphine acts above all on the mu receptor subtype of the spinal cord. ⋯ All parameters were evaluated daily for a period of 20+/-5 days. The results indicate that in group TTDS there was an improvement of pain symptomatology, also confirmed by the increased hours of sleep and the lower incidence of side effects. Instead in group NM, pain control was less effective, 18 patients needed a rescue dose of morphine, and the incidence of side effects increased.
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Minerva anestesiologica · Jul 2005
Editorial Biography Historical ArticleJohn J. Bonica. A biography.