Minerva anestesiologica
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Minerva anestesiologica · May 2008
Randomized Controlled Trial Comparative StudyEfficacy of propofol compared to midazolam as an intravenous premedication agent.
It is common practice to administer a premedication to patients about to undergo anesthesia. This study compared the effects of a small intravenous bolus of propofol versus midazolam administered as a premedication. ⋯ Propofol may be an economical and safe alternative to midazolam for i.v. premedication.
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An early diagnosis of sepsis prior to the onset of clinical decline is of particular interest to health practitioners because this information increases the possibilities for early and specific treatment of this life threatening condition. In comparison to acute myocardial infarction or ischemic stroke, the time to initiate therapy is thought to be crucial and the major determining factor for surviving sepsis. The treatment of severe sepsis and septic shock consists of source control, early antimicrobial therapy, and supportive and adjunctive therapies. ⋯ However, implementing new medical advances in the management of sepsis into daily clinical intensive care remains a major hurdle. High quality management tools are necessary to bring evidence-based therapy to the bedside. With respect to recently published studies, the importance of the time taken to improve the outcome of sepsis can not be overemphasized.