Minerva anestesiologica
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Minerva anestesiologica · May 2014
Influence of apneic oxygenation and minimal tidal volumes on ventilator associated lung injury.
Protective tidal volumes such as 6 mL/kg can still result in tidal hyperinflation and expose the lung to mechanical stress. Further reduction of tidal volume and apneic oxygenation might mitigate lung injury. We aimed to assess the influence of minimal tidal volumes and apneic oxygenation in combination with arterio-venous extracorporeal lung assist (av-ECLA) on ventilator-associated lung injury. ⋯ In combination with highly effective CO2-removal, the reduction of tidal volumes up to 0 mL was feasible. Tidal hyperinflation could be reduced in the upper lung areas, yet inflammation in the lower lung was higher with low tidal volumes. This stresses the differing mechanical properties of inhomogeneous injured lungs.
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Minerva anestesiologica · May 2014
Review Meta AnalysisEfficacy and safety of gabapentin for treatment of post-herpetic neuralgia: a meta-analysis of randomized controlled trials.
Postherpetic neuralgia (PHN) is a common type of neuropathic pain occurring after resolution of herpes zoster rash. Although gabapentin is a widely used treatment, some disagreements exist about its efficacy and safety. Meta-analysis was performed to better evaluate the efficacy and safety of gabapentin for management of PHN. ⋯ This meta-analysis indicates that gabapentin is an effective and well-tolerated treatment for patients with PHN.