Minerva anestesiologica
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Minerva anestesiologica · Sep 2014
Observational StudyPreoperative depression and hospital length of stay in surgical patients.
The association of depression and hospital length of stay (LOS) has rarely been examined in surgical patients outside of cardiovascular surgery. This study investigates whether clinically significant preoperative depression shows an independent association with LOS in patients from various surgical fields after adjusting for age, gender and important somatic factors. ⋯ Data suggest that the association of depression and LOS is independent of the impact of age, gender, surgical field, preoperative physical health, severity of medical comorbidity and extent of surgical procedure. Integration of depression therapy into routine care of surgical patients might be an option to improve outcomes.
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Minerva anestesiologica · Sep 2014
USE OF THE PARENTERAL ANTIBIOTIC ERTAPENEM AS SHORT TERM PROPHYLAXIS IN BARIATRIC SURGERY: A PHARMACOKINETICPHARMACODYNAMIC STUDY IN CLASS III OBESE FEMALE PATIENTS.
The objective of this study was to determine the pharmacokinetics-pharmacodynamics (PK/PD) of Ertapenem in extremely obese female patients (Body Mass Index [BMI] ≥ 40 kg/m²) undergoing bariatric surgery. ⋯ Our data suggest that in extremely obese female patients, the standard dose of 1 g i.v. Ertapenem as short term prophylaxis may not provide optimal clinical levels of free drug for prevention of surgical site infections.