Minerva anestesiologica
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Minerva anestesiologica · Mar 2016
Dynamic view of postoperative pain and quality of life evolution after total knee arthroplasty - a prospective observational study.
Systemic response to cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) causes the activation of endocrine, metabolic, hemodynamic and inflammatory processes. The aim of this work is to describe and analyze the time course of the inflammatory markers concentration during CRS+HIPEC in plasma and peritoneal fluids and the association with hemodynamic and metabolic parameters. ⋯ The most significant variations were in IL-6 and PCT levels. The cytokines level parallels the hemodynamic derangements. Treatment during HIPEC should mimic the established treatment during sepsis and septic shock.
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Minerva anestesiologica · Mar 2016
Comparative StudyComparison of blood culture and multiplex real-time pcr for the diagnosis of nosocomial sepsis.
In many cases of suspected sepsis, causative microorganisms cannot be isolated. Multiplex real-time PCR generates results more rapidly than conventional blood culture systems. ⋯ SeptiFast may be useful when added to blood culture in the diagnosis and management of sepsis.
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Minerva anestesiologica · Mar 2016
Observational StudyDynamic view of postoperative pain evolution after total knee arthroplasty: a prospective observational study.
Having a dynamic view of postoperative pain resolution allows a better understanding of the transition towards chronic pain. Sleep and quality of life are important determinants of satisfaction after total knee arthroplasty (TKA), besides functional recovery and pain. ⋯ The trajectories of the different types of pain after TKA show their non-linear evolution, highlighting the need of a better pain control at precise moments. Sleep disturbances and alterations of quality of life are still present one year after the surgery.
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Minerva anestesiologica · Mar 2016
Potential neurotoxicity of anaesthetic drugs in young children - Who cares? A survey among European anaesthetists.
Potential neurotoxicity of anesthetic drugs is currently one of the most intensely discussed issues in pediatric anesthesia. Prospective human data are sorely lacking and there is an on-going debate among experts in the field whether one should (or can) extrapolate animal data to humans. Data regarding the thoughts of practicing anesthetists regarding this topic have not been published. ⋯ Practicing anesthetists care about potential neurotoxicity of anesthetic drugs in young children. Colleagues working in children's hospital have slightly different attitudes to deal with the topic, compared to those working in general hospitals. The vast majority of our colleagues are waiting for prospective human research data that may help to unravel the current controversy surrounding potential anesthetic drug neurotoxicity and help to improve the safety of pediatric anesthesia.