Minerva anestesiologica
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Minerva anestesiologica · Oct 2017
Survey on monitoring analgesia and sedation in the Italian Pediatric Intensive Care Units.
Admission in Pediatric Intensive Care Unit requires management and monitoring of analgesia and sedation, in order to reduce their adverse effects, and to prevent withdrawal syndrome and delirium. The aim of this study was to evaluate the management of analgesia and sedation in critically ill children admitted in the Italian Pediatric Intensive Care Units. ⋯ Despite an increasing sensitivity in pain and sedation management over the last five years, knowledge and monitoring of abstinence syndrome and delirium need to be improved.
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Minerva anestesiologica · Oct 2017
Colon epithelial injury in critically ill colectomized patients: aberration of tight junction proteins and Toll-like receptors.
Abnormal permeability and extensive epithelial injury are characteristic of colon wall damage complicating critical illness, such as sepsis, and associated with mortality. To assess mechanisms of such colon epithelial disruption, we studied expression of markers of innate immunity and intercellular junctions in patients with critical illness. ⋯ Down-regulation of claudin‑1 and up-regulation of TLR9 suggest that epithelial barrier dysfunction and innate immunity activation are involved in the pathogenesis of colon epithelial injury in patients with critical illness.