Minerva anestesiologica
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Minerva anestesiologica · Aug 2017
Evaluation of eight biomarkers to predict short term mortality in patients with acute severe dyspnea.
Being able to better predict risk and optimal care for patients presenting with acute dyspnea is critical. Prognostic biomarkers are well known: amino-terminal pro-B-type Natriuretic Peptide, troponin, C-reactive protein, procalcitonin. Some were more recently developed: mid-regional pro-A-type natriuretic peptide (Mid Pro-ANP), mid-regional-pro-adrenomedullin (MR-proADM), pro-endothelin, copeptin. The aim of the paper was to evaluate prognostic value of clinical findings and 8 biomarkers in patients with severe acute dyspnea. ⋯ Biomarkers can contribute to determine the day-28 outcome of patients with acute severe dyspnea.
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Minerva anestesiologica · Aug 2017
Randomized Controlled TrialRetromolar laryngoscopy: a randomised cross-over vocal cords visualisation study.
Vocal cords visualization is a major determinant for successful tracheal intubation. The aim of our study was to compare vocal cord visualization by using conventional direct laryngoscopy with retromolar direct laryngoscopy in patients with an existing retromolar gap at the right mandible. ⋯ In summary, laryngoscopy via the retromolar method by using a Miller blade #4 lead to a significantly better vocal cord visualization compared to the conventional method performed with a Macintosh blade #3 in patients with an existing retromolar gap on the right side.
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Minerva anestesiologica · Aug 2017
Randomized Controlled Trial Clinical TrialNeuromuscular effect of dexmedetomidine on sevoflurane: an open-label, dose-escalation clinical trial.
Sevoflurane presents reliable central neuromuscular effects. However, little knowledge is available regarding the interaction between sevoflurane and demedetomidine. We evaluated the neuromuscular effect of dexmedetomidine on sevoflurane in patients with normal neuromuscular transmission and calculated the 50% effective concentration (EC50). ⋯ Sevoflurane has a concentration-dependent central neuromuscular effect in patients with normal neuromuscular transmission. Intravenous dexmedetomidine dose-dependently decreases the neuromuscular EC50 of sevoflurane.