Minerva anestesiologica
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We describe our most recent findings about the use of epinephrine for cardiac arrest particularly referring to the mechanism of action, doses, modalities of administration and action on the cerebral circulation. Epinephrine is the elective drug in cardiocerebral resuscitation; but its use does not modify the final results which are still unsatisfying. The percentage of patients surviving cardiac arrest is very low, and many of them suffer important neurological damage.
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Minerva anestesiologica · Jul 1991
Randomized Controlled Trial Clinical Trial[Clonidine and postoperative shivering].
Clonidine was clinically evaluated to suppress postoperative shivering in 60 patients who had undergone anesthesia for general, thoracic and vascular surgery. The study was carried out in double blind conditions with comparison of two doses (75 and 150 micrograms) of clonidine, one dose of methylphenidate, and one dose of saline, as control group. The level of inhibition (Goldfarb scale), haemodynamics and temperature were studied. In conclusion, the methylphenidate is drug first choice for postoperative shivering, but clonidine inhibits postoperative shivering without haemodynamic and temperature variations (75 micrograms).