World Neurosurg
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To present a unique case of a brainstem Curvularia fungal infection and review the diagnosis and management of this rare phenomenon. ⋯ This is the first reported case of a brainstem Curvularia infection. This case highlights the importance of an aggressive surgical and antibiotic therapy in the treatment of central nervous system Curvularia infections. There appears to be a strong relationship between heavy marijuana use and Curvularia infection, producing lung granulomas that may extend to other organs such as the central nervous system of immunocompetent patients.
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Patients with cerebral sinus and cortical venous thrombosis develop venous infarcts in approximately 50% of cases, resulting in serious clinical symptoms. An animal model is needed to further clarify the underlying mechanisms and consequences surrounding cerebral venous sinus thrombosis, particularly for severe ones. ⋯ We suggest that our modified model of superior sagittal sinus thrombosis, involving cortical veins, is suitable for the study of its underlying mechanisms, as well as therapeutic approaches directed at the disease.