World Neurosurg
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Controlled Clinical Trial
Supplementary Motor Cortical Changes Explored by Resting-state Functional Connectivity in Brachial Plexus Injury.
Brachial plexus injury (BPI) is a serious peripheral nerve injury, and clinical outcomes are generally unsatisfactory. It has been reported that cortical plasticity could influence the restoration of motor function. However, the neurologic mechanism of BPI is unclear, which provides a basis for further investigation. The supplementary motor area (SMA) plays an important role in the regulation of motor function. This study aims to explore SMA-whole brain functional connectivity after deafferentation of the brachial plexus. ⋯ Patients with BPI showed weakened functional connectivity between hand grasp-related areas and the SMA and multiple regions associated with motor processing or information integration. A clear image of the functional status of the brain after deafferentation was provided. On the basis of this discovery, a relationship between changes in neuroimaging measurements and clinical outcomes can be determined in future studies.
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Thrombosed brain aneurysm is usually treated by cerebrovascular surgery rather than endovascular surgery. The basilar-superior cerebellar artery (BA-SCA) aneurysm can be accessed via the transsylvian, temporopolar, or anterior temporal approaches. However, a disadvantage of these approaches is that the surgical route is obstructed by the internal carotid artery (ICA). Therefore, we propose that after establishing a high-flow bypass, severing the ICA will enable safe clipping of a BA-SCA aneurysm. ⋯ Intentional severing of the ICA after establishing a high-flow bypass will not become the standard technique for treatment of upper basilar artery aneurysms. However, this technique can extend the operative field to allow clipping of an upper basilar artery aneurysm after several skull base techniques.
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Controlled Clinical Trial
Endoscopic Third Ventriculostomy Instead of Shunt Revision in Children Aged Younger Than 3 Years.
Endoscopic third ventriculostomy (ETV) is a valuable option in the treatment of shunt failure, but no clinical data exist for young children. The aim of this study was to elucidate the role of ETV in patients younger than 3 years of age with shunt malfunction. ⋯ Patients younger than 3 years with obstructive or communicating hydrocephalus may benefit from ETV in the event of shunt malfunction and have about a 60% probability of becoming shunt free.
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Surgery for elderly patients with acute subdural hematomas (ASDH) is controversial, because postoperative mortality rates are reported to be high and long-term outcomes unknown. Thus, we aimed to describe midterm and long-term mortality rates of elderly patients operated for an ASDH. ⋯ In this first surgical case series of 75-year-old or older patients with ASDH, the overall mortality rate appears to be relatively low, especially for preoperatively conscious and independent patients without antithrombotic medication. Patients alive at 1-year after surgery had a life expectancy comparable to their age-matched peers. The prognosis seems to be detrimental for preoperatively unconscious patients who were functionally dependent or used antithrombotic medication before the injury.
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Case Reports
Primary intracranial epidermoid carcinoma with diffuse leptomeningeal carcinomatosis: Report of two cases.
Malignant degeneration of epidermoid cyst (EC) with accompanying leptomeningeal carcinomatosis (LC) at presentation is extremely rare. We add two cases to the literature, including the first case of primary brainstem involvement with simultaneous diffuse LC, and discuss clinical and radiological cues to differentiate benign and malignant epidermoid tumors for early diagnosis. ⋯ These cases illustrate that a high index of clinical suspicion is necessary for early diagnosis of disseminated disease in cases of recurrent episodes of aseptic meningitis. In cases of primary benign EC, aggressive resection should be attempted to reduce the risk of malignant degeneration. A separate biopsy specimen from the enhancing portion of the tumor is used to rule out an underlying coexisting malignancy. Multimodal management carries the best prognosis for primary intracranial squamous cell carcinoma with LC.