World Neurosurg
-
We sought to inspect the role of AMD3100, which acts as an antagonist of stromal cell-derived factor-1/CXC chemokine receptor 4 on the formation of neointima in rabbit saccular aneurysm after flow diverter (FD) treatment. ⋯ Interval use of AMD3100 promotes the formation of neointima in rabbit saccular aneurysm and facilitates the endothelialization of the neointima after FD treatment.
-
High cervical myelopathy is a common entity and often encountered in clinical practice. Various pathologies can present with this symptomatology. ⋯ Non tuberculous ANCA positive pachymeningitis is a rare entity and a diagnosis of exclusion or following histopathological confirmation. Here we describe a case of high cervical myelopathy, the presentation, imaging and the various differentials considered and how we arrived at the diagnosis.
-
The role of the dominant hippocampus in verbal and episodic memory recall has been extensively investigated. However, there are categories of memory estimated independent of hippocampal function. In particular, factual knowledge is solely constituted from written or spoken input independent on undertaken experience, but the temporal structures involved are not well defined. ⋯ Using fMRI, we visualized a circumscribed brain area within the parahippocampal gyrus during factual knowledge retrieval, the lesioning of which led to factual knowledge deficits. Thus, impairment of factual knowledge retrieval may occur if resection is extended into the parahippocampal gyrus. Preoperative fMRI memory maps may contribute to avoiding such deficits.
-
Health care-associated meningitis and ventriculitis (HCAMV) occurs in adults with intracranial hemorrhage (ICH) and is associated with high rates of morbidity and mortality, but the prognostic impact of this infectious complication in a controlled matched study of ICH is unknown. ⋯ HCAMV has a significant prognostic impact in adults with ICH.
-
Various authors have described the morphology of the alar ligaments; however, there are no reports of a cadaveric study focusing on their attachments onto the dens. The purpose of this study was to use fresh cadaveric specimens to describe in detail different attachment patterns of the alar ligaments onto the dens. ⋯ Wide posterolateral anchoring to the dens coupled with the nearly horizontal trajectory explains the biomechanical advantage of the alar ligaments in undertaking a stabilizing function in limiting head rotation that would otherwise be ineffective in the case of weaker attachments or a more vertical orientation.