World Neurosurg
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More data regarding complications in neurosurgery residents' cases are needed to assess patients' safety during hands-on surgical education. ⋯ The results of the current study in addition to the literature on neurosurgery resident training support the safety of supervised early surgical education for shunt surgery.
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A retrospective review of the surgical outcome for patients with craniopharyngioma (CP) treated in a single neurosurgical center with surgical resection using visualization to ensure hypothalamic preservation. ⋯ This study has shown that radical surgical resection of CP using microsurgical excision can be effective with a good patient outcome without more limitations on each individual tumor of distinct features despite the impact of recent endoscopic techniques on CP surgery. The surgical approach depends on a direct and wider visualization of CP located in the midline with preserving hypothalamic structures by identifying some hypothalamic landmark structures. After surgery, most patients can resume their normal activities even after aggressive tumor removal, although patients require postoperative hormonal replacement.
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Review Biography Historical Article
Usher Parsons (1788-1868) and his 19(th) Century Understanding and Surgical Treatment of Spinal Curvatures.
Usher Parsons was a prominent surgeon in the 19th century. However, his contributions to the understanding and treatment of spinal curvatures have been largely forgotten. ⋯ This glimpse into history offers insight into the thought processes and surgical strategies that were available in the early 19th century. It is pioneers in this field, such as Usher Parsons, on which our current understanding of spinal curvatures and its treatment is built.
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Multicenter Study
Therapy for recurrent high-grade gliomas: Results of a prospective multicenter study on health-related quality of life.
To assess the impact of therapy on patients' health-related quality of life (HRQoL) in recurrent high-grade glioma (HGG) in an unselected cohort. ⋯ Our results from an unselected cohort of recurrent HGGs show that the currently available treatment options have no negative impact on HRQoL. Thus, treatment decisions can be made individually, without fear of jeopardizing HRQoL for better survival. Only, the third recurrent surgery remains a very individual decision even in younger patients with high Karnofsky Performance Score.
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Glioblastoma (GBM) is an aggressive central nervous system cancer with poor prognosis despite maximal therapy. The recent advent of immunotherapy holds great promise for improving GBM survival and has already made great strides toward changing management strategies. ⋯ Emerging theories involving the tumor mutational landscape and microbiome have also been explored in relation to cancer treatment. Although identification of novel biomarkers may improve and help direct treatment of patients with GBM, the next step is to explore the role of biomarkers in precision medicine and selection of specific immunotherapeutic drugs in an individualized manner.